In vitro embryo production in equids has traditionally focused on horses, but recent advances are expanding its reach across the entire family, including donkeys, mules and even zebras. This presentation explores key milestones and lessons learned from applying assisted reproductive technologies (ART) across multiple equid species, highlighting both the shared biology and species-specific challenges that shape success. Drawing on a decade of research, this talk will cover the production of the first cloned horses in South America and Australia, the first ICSI-generated embryos in donkeys and mules, and the first cloned zebra embryos. By examining how these closely related species respond we can better understand the biological and technical barriers to reproductive success. This comparative approach not only improves outcomes in equid domestic breeding programs but also opens new possibilities for human reproductive medicine and wildlife conservation. From stables to savannahs, ART in equids is evolving and with it, our ability to support reproduction across one extraordinary family.