Oral Presentation ESA-SRB-ANZOS 2025 in conjunction with ENSA

Inhibition of mtDNA replication by oocyte specific deletion of Polg leads to premature ovarian insufficiency in mice (128487)

Ziyi Sha 1 , Deepak Adhikari 1 , John Carroll 1
  1. Department of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Melbourne, Victoria, Australia
Publish consent withheld
  1. 1, Hance N, Ekstrand MI, Trifunovic A. Mitochondrial DNA polymerase gamma is essential for mammalian embryogenesis. Hum Mol Genet. 2005;14(13):1775-83. 2, Bond, S.T., King, E.J., Walker, S.M. et al. Mitochondrial damage in muscle specific PolG mutant mice activates the integrated stress response and disrupts the mitochondrial folate cycle. Nat Commun 16, 2338 (2025). https://doi.org/10.1038/s41467-025-57299-3