Successful implantation and pregnancy rely on highly dynamic remodeling of the uterus and coordinated signaling with the embryo. Failures in these processes are a leading cause of infertility, yet conventional genetic models have limited ability to reflect human disease. Most alter gene expression from conception, whereas in women, molecular disruptions often arise later in reproductive life. I present a novel inducible, tissue-specific genetic model that we developed to enable precise temporal control of gene expression in the uterus with applications in other reproductive tissues including placenta. This approach preserves normal embryonic development while allowing functional interrogation of key pathways during the peri-implantation window and beyond. Unlike traditional knockout strategies, this system can be applied broadly to investigate any gene in reproductive tissues, offering a versatile platform to uncover mechanisms of infertility, implantation failure, and pregnancy complications. This innovation represents a powerful step toward more realistic modeling of human reproductive disorders and accelerates discovery of potential therapeutic targets.