Invited Talk ESA-SRB-ANZOS 2025 in conjunction with ENSA

Mapping interactions between dietary macronutrients and sex across the lifecourse (130674)

Amanda Brandon 1 2 , Tamara Pulpitel 1 2 , Carsten Schmitz-Peiffer 1 2 , Lewin Small 1 2 , Alistair Senior 1 2 , Tahlia L Fulton 1 2 , Sophie Stonehouse 1 2 , Letisha Prescott 1 2 , Alyssa Face 1 2 , K. Saiful Islam 1 2 , Jenny E Gunton 3 4 , Jacob George 4 , David Raubenheimer 1 2 , Gregory J Cooney 1 3 , David G Le Couteur 1 5 6 , Stephen J Simpson 1 2
  1. Charles Perkins Centre, The University of Sydney, Sydney, NSW, Australia
  2. School of Life and Environmental Science, The University of Sydney, Sydney, NSW, Australia
  3. Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia
  4. Storr Liver Centre, Westmead Institute for Medical Research, Westmead Hospital Sydney, Sydney, NSW, Australia
  5. Centre for Education and Research on Ageing, Concord RG Hospital, Concord, NSW, Australia
  6. ANZAC Research Institute, Sydney, NSW, Australia

Understanding mechanisms that define the relationship between diet, physiology, and ageing holds great promise to improve human health despite the complexity of these relationships. Traditional dietary approaches have usually focussed on ‘one-nutrient-at-a-time’ rather than considering the entire nutrient and dietary landscape. In this talk I will discuss how we have employed an integrative approach called the Geometric Framework for Nutrition (GFN) to explore in unprecedented detail the ways that nutrients and their interactions influence the multiple dimensions of phenotype (spanning molecular interactions to life-history traits) across life.