Early-life reproductive effort can trade-off against late-life fertility but why this occurs is poorly understood. We have conducted a series of experiments that test whether different aspects of early-life reproduction influence reproductive aging in mice. We find that pregnancy and lactation hasten the age at which females become infertile, but allowing females to mate in the absence of pregnancy has the opposite effect. Females exposed to vasectomized males early in life have improved late-life fertility, which is linked to better embryo survival during pregnancy and an ability to produce litters at a quicker rate. We hypothesize that periods of suppressed ovulation after mating lead to less ovarian damage, supporting late-life fertility. We will also present preliminary results from a long-term experiment that establishes whether long-term suppression of puberty, or suppression of estrus cycling in adulthood, induced pharmacologically, influences subsequent female fertility and reproductive aging. This experimental model somewhat mimics the effects of early-life dietary restriction on fertility, which can lead to extended reproductive lifespan, but in the absence of altered food intake or body weight changes.